Prevalence of Occult Hepatitis B in Patients with Lupus Nephritis and Glomerulopathy Referred to Shahid Sadoughi Hospital in Yazd, Iran

Farzaneh Najafi, Mahmood Baghbanian, Zahra Danaii


Background: The conventional method for testing Hepatitis B (HBsAg) can be not detected  occult Hepatitis B in patients. No diagnosis of hepatitis B in patients with lupus nephritis and glomerulopathy treated with Immunosuppressive drugs, can be clear Hepatitis B. Also, due to the possible role of occult Hepatitis B in the lack of a complete response to treatment and continue proteinuria Assess the prevalence of occult Hepatitis B in these patients is this study we decided to the survey Prevalence of occult hepatitis B in patients with lupus nephritis and glomerulopathy referred to SHAHID SADOUGHI Hospital in Yazd.

Methods: This study was a descriptive-cross sectional study. A total of 112 patients with lupus nephritis and glomerulopathy referred to internal department, nephrology and rheumatology clinic of SHAHID SADOUGHI Hospital in five-year period studied. HBsAg, HBsAb was measured in patients and those with HBsAg positive and HBsAg negative HBV-DNA was measured. Demographic was collected in the questionnaire that already provided. The collected data were entered into SPSS version 20, using statistical tests were analyzed.

Result: The results showed that the mean age of participants was 40.84 ± 15.11 years. From 112 patients participated in the study,49 patients (43.8%) were men and63 patients (56.2%) were female. Also from 112 patients,97 patients (86.6%) had primary glomerulopathy and 15 patients (13.4%) had lupus nephritis. The prevalence of occult hepatitis B was 3.0% in patients with primary glomerulopathy and 13.3% in lupus nephritis patients. There was a significant relationship between the frequency of HBc-Ab and the mean age of patients with type of disease (P-value <0.05).

Conclusion: The prevalence of occult hepatitis B in patients with lupus nephritis was greater than the prevalence in pateints with gleumeronephritis.



occult hepatitis B, lupus nephritis, glomerulopathy

Full Text:



Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J. Harrison's Principles of Internal Medicine 18E Vol 2 EB. McGraw Hill Professional; 2012 Nov 8.

Helaly GF, El Ghazzawi EF, Shawky SM, Farag FM. Occult hepatitis B virus infection among chronic hemodialysis patients in Alexandria, Egypt. Journal of infection and public health. 2015 Dec 31;8(6):562-9.

Du W, Zheng Z, Han S, Ma S, Chen S. HBV reactivation in an occult HBV infection patient treated with prednisone for nephrotic syndrome: case report and literature review. BMC infectious diseases. 2013 Aug 27;13(1):394.

Liu T, Yang S, Yue Z, Kuang Y, Guan W, Sun L. Clinical and pathological characteristics of 5 children with HBV surface antigen (HBsAg)-negative hepatitis B virus-associated glomerulonephritis. Journal of Clinical Virology. 2015 May 31;66:1-5.

Alavian SM, Hajarizadeh B, Ahmadzad-Asl M, Kabir A, Bagheri-Lankarani K. Hepatitis B Virus infection in Iran: A systematic review. Hepatitis monthly. 2008 Oct 1;8(4).

Sui M, Wu R, Zhang J. Jiang.Low prevalence of hepatitis B virus infection in patients with autoimmune diseases in a Chinese patient population. Journal of Viral Hepatitis. ;2014(21):925-929.

Watanabe R, Ishii T, Kobayashi H, Asahina I, Takemori H, Izumiyama T,et all.Prevalence of Hepatitis B Virus Infection in Patients with Rheumatic Diseases in Tohoku Area: A Retrospective Multicenter Survey Tohoku .J Exp Med.2014; 233:129-131.

Lil H, Yuan X, Linlin Q, Qiaoling Z and Xiao1 P.Efficacy of adefovir dipivoxil combined with a corticosteroid in 38 cases of nephrotic syndrome induced by hepatitis B virus-associated glomerulonephritis, Ren Fail. 2014; 36(9): 1404–1406.

Samih H. Nasr1, Jai R and Vivette D. Bacterial infection–related glomerulonephritis in adults. International Society of Nephrology.2013:60-5.

Yoo J, Lee JH, Yoon JH, Lee M,et al.Hepatitis B Virus-Related Glomerulonephritis:Not a Predominant Cause of Proteinuria in Korean Patients with Chronic Hepatitis B Received 15 October 2014.

Hitesh H, Chinmay P and Kenar D. Complete Remission of Hepatitis B Virus-Associated Nephrotic Syndrome from IgA Nephropathy Following Peginterferon Therapy, Renal Failure.2013; 35(2): 295–298.

Robinson WS. Hepadnaviridae and their replication. In: Virology Fields BN, Knipe DM. Raven New York. 1996: 2137-2169.

Holger Hennig, Ines PuCHta, Jurgen Luhm et al. Frequency and load of hepatitis B virus DNA in firsttime blood donors with antibodies to hepatitis B core antigen. Blood 2002: 100 (7), 2637-2641.

Brechot C, Thiers V, Kremsdorf D, Nalpas B, Pol S, Paterlini- Brechot P. Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: clinically significant or purely ‘occult’? Hepatology 2001: 34, 194–206.

Grob P, Jilg W, Bornhak H et al. Serological pattern 'anti- HBc alone': report on a workshop. J Med Virol 2000: 62, 450–455.

Gerald Y. Minuk, Dong S,Rebecca , Manna ZH, Kimberly H,Julia H, et al.. Occult Hepatitis B Virus Infection in a North American Adult Hemodialysis Patient Population. HEPATOLOGY.2004; 40:1072–1077.

F. FABRIZI, MESSA PG, LUNGHI G, AUCELLA ,et al.Occult hepatitis B virus infection in dialysis patients: a multicentre Survey. Aliment Pharmacy Therapy .2005; 21:1341–1347.

Hisham I.Occult hepatitis B virus infection in Egyptian hemodialysis patients with or without hepatitis C virus infection.2010

Keyvani H, Agah S, Kabir A, Alavian SM-Prevalence and risk factors of isolated anti-HBc antibody and occult hepatitis B infection in hemodialysis patients: a nationwide study. Hepatitis J.2013.

Abbasi A, Tajbakhsh H, Kabotari Y. Occult Hepatitis B Virus Infection in Chronic Hemodialysis Patients in Panje-Azar Hospital,Gorgan. Tehran university J.2006.

Karimi-Zarchi M, Tabatabaie A, Dehghani-Firoozabadi A, Shamsi F, Baghianimoghaddam M, Dargahi M, Yazian P, Mojahed S. The Most Common Type of HPV in Women with Atypical Squamous Cell of Undetermined Significance (ASCUS) in Pap Smear in Iran-Yazd. International journal of biomedical science: IJBS. 2015 Dec;11(4):173.


  • There are currently no refbacks.