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Keywords

Vitamin D
Colon Polyps
cancer

How to Cite

Fatima, S. F., Hassan, S. Z., Khan, S. K., & Bhali, A. (2019). Linkage Between Serum Vitamin D and Precancerous Colon Polyps: Letter to Editor. Internal Medicine and Medical Investigation Journal, 4(2). https://doi.org/10.24200/imminv.v4i2.181

Abstract

Colon cancer is the third most common type of cancer in the USA and accounts yearly for 11% of all cancer deaths (Center for Disease Control and American Cancer Society). Thus, identifying strategies that reduce its incidence is critically important. Calcitriol, the most active form of vitamin D, is a pleotropic hormone with a wide range of biological activities. Due to its ability to regulate calcium and phosphate metabolism, 1,25D3 plays a major role in bone health. In addition, 1,25D3 binds to the vitamin D receptor and thereby regulates the expression of a number of genes which control growth, differentiation and survival of cancer cells. Although a well-recognized physiological role of vitamin D is the regulation of calcium and phosphate metabolism, recent studies suggest a much broader range of biological functions of vitamin D, including potential anti-neoplastic effects. Garland et al. discovered in 1980 that colon cancer mortality rates in the U.S. were highest in places where populations were exposed to the least amount of sunlight, and proposed that vitamin D might be a protective factor against colon cancer. Since then, extensive studies have reported anti-neoplastic actions of vitamin D, particularly in colorectal cancer. 

https://doi.org/10.24200/imminv.v4i2.181
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References

Juniku-Shkololli A, Manxhuka-Kerliu S, Ahmetaj H, Khare V, Zekaj S. Expression of immunohistochemical markers of progression in pre-cancerous and cancerous human colon: Correlation with serum vitamin D levels. Anticancer research. 2015 Mar 1;35(3):1513-20.

Dou R, Ng K, Giovannucci EL, Manson JE, Qian ZR, Ogino S. Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence. British Journal of Nutrition. 2016 May;115(9):1643-60.

Weingarten MA, Trestioreanu AZ, Yaphe J.Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane database of systematic reviews. 2008(1).

Crockett SD, Barry EL, Mott LA, Ahnen DJ, Robertson DJ, Anderson JC, Wallace K, Burke CA, Bresali-er RS, Figueiredo JC, Snover DC. Calcium and vitamin D supplementation and increased risk of serrated polyps: results from a randomised clinical trial. Gut. 2019 Mar 1;68(3):475-86.

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