Letter to Editor
Published February 10, 2019
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Keywords

Proton pump inhibitors
Gastric ulcers
Gastric carcinoma

How to Cite

Haq, A., Uddin, S. M. M., & Yaqoob, U. (2019). Proton pump inhibitors and Gastric cancer correlation; Time to take it seriously?”. Internal Medicine and Medical Investigation Journal, 4(1). https://doi.org/10.24200/imminv.v4i1.188

Proton pump inhibitors and Gastric cancer correlation; Time to take it seriously?”

Aatera Haq
Civil Hospital Karachi
Syed Mohammad Mazhar Uddin
Civil Hospital Karachi
Uzair Yaqoob
Dow University of Health Sciences
http://orcid.org/0000-0002-5910-2875

Proton pump inhibitors (PPI) are the most prescribed drugs globally, which are highly potent gastric acid suppressors, known for the management of numerous diseases. There is a notable correlation between Gastric cancer and PPI. It is highlighted that the underlying mechanism is in close association with a study conducted 30 years ago, which showed excessive inhibition of gastric acid secretion in rodents, with secondary hypergastrinemia, that led to enterochromaffin-like-cell (ECL) hyperplasia. In conclusion, based on the scarce literature, it is evident that the safety of PPI is under a dilemma. Developing countries like Pakistan, where there is an excessive prescription of PPI, often without justification, are a significant burden on the economy as well as a threat to life, keeping in view of the significant correlation between PPI and gastric cancer.

https://doi.org/10.24200/imminv.v4i1.188
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References

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Waldum HL, Fossmark R. Proton pump inhibitors and gastric cancer: a long expected side effect finally reported also in man. Gut. 2017.

Havu N. Enterochromaffin-like cell carcinoids of gastric mucosa in rats after life-long inhibition of gastric secretion. Digestion. 1986,35(Suppl. 1):42-55.

Naqvi SH, Saqib SM, Khan WA, Syed IA. Rising use of Proton Pump inhibitors: A Karachi perspective. Sci Int (Lahore). 2014, 26:1941-4.

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