CORRELATION OF MUSCLE STRENGTH AND MASS WITH BONE MINERAL DENSITY IN POSTMENOPAUSAL WOMEN

Mayra Rojas

Abstract

Introduction: Osteoporosis is a systemic disease of the bone, which entails an increased risk of fracture, with high impact on morbidity, mortality and costs in the health system. Several studies have shown a relationship between muscle mass and strength with bone mineral density (BMD). Our objective is to determine the correlation between these variables in postmenopausal women.

Methods: Correlation study. 100 postmenopausal women older than 50 years were selected randomly and a sociodemographic survey was applied to them, muscle strength was determined by manual grip strength, which was measured with a digital dynamometer. BMD measurements and muscle mass were obtained with densitometry. The correlation between strength, muscle mass and BMD was determined by a Spearman correlation.

Results: The average age was 62.8 ± 7.48. Femur and column BMD where significantly related to the muscle mass index (MMI), weight and body mass index. The prevalence of fragility fracture was 17%. BMD of the femur was lower in patients with fragile fracture and there was a negative and significant correlation between femur BMD and skeletal muscle mass index (SMMI).

Conclusions: Bone health studies should include the study of MMI and the SMMI. The improvement of the MMI can influence femoral and vertebral BMD with significant impact on fragility fractures. This is the first study of its kind conducted in Colombia and South America.

 

Keywords

Muscular strength, muscle mass, bone mineral density

References

Pereira MIR, Gomes PSC. Muscular strength and endurance tests: reliability and prediction of one repetition maximum-Review and new evidences. Rev Bras Med Esporte. 2003;9(5):325-35.

Prof José Zanchetta MD. THE LATIN AMERICA REGIONAL AUDIT www.iofbonehealth.org Epidemiology, costs & burden of osteoporosis in 2012. 2012;1-76.

Lindsay R. The menopause and osteoporosis. Obstet Gynecol. 1996;87(2):16S-19S.

Lindsay R, Hart DM, Forrest C, Baird C. Prevention of spinal osteoporosis in oophorectomised women. The Lancet. 1980;316(8205):1151-4.

CHRISTIANSEN C, RIIS BJ. Five years with continuous combined oestrogen/progestogen therapy. Effects on calcium metabolism, lipoproteins, and bleeding pattern. BJOG Int J Obstet Gynaecol. 1990;97(12):1087-92.

Curtis E, Litwic A, Cooper C, Dennison E. Determinants of muscle and bone aging. J Cell Physiol. 2015;230(11):2618-25.

Moon S-S. Relationship of lean body mass with bone mass and bone mineral density in the general Korean population. Endocrine. 2014;47(1):234-43.

Mastaglia S. Osteosarcopenia: a risk factor for osteoporotic fractures. ACTA Bioquim Clin Latinoam. 2016;50(3):357-65.

Hughes VA, Frontera WR, Roubenoff R, Evans WJ, Singh MAF. Longitudinal changes in body composition in older men and women: role of body weight change and physical activity. Am J Clin Nutr. 2002;76(2):473-81.

Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, Di Iorio A, et al. Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol. 2003;95(5):1851-60.

Lexell J, Taylor CC, Sjöström M. What is the cause of the ageing atrophy?: Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15-to 83-year-old men. J Neurol Sci. 1988;84(2-3):275-94.

von Haehling S, Morley JE, Anker SD. From muscle wasting to sarcopenia and myopenia: update 2012. J Cachexia Sarcopenia Muscle. 2012;3(4):213-7.

Villada FAP, Franco SAA, de Paz Fernández JA. Sarcopenia in community-dwelling persons over 60 years of age from a northern Spanish city: relationship between diagnostic criteria and association with the functional performance. Nutr Hosp. 2015;31(5):2154-60.

Zhou Z, Zheng L, Wei D, Ye M, Li X. Muscular strength measurements indicate bone mineral density loss in postmenopausal women. Clin Interv Aging. 2013;8:1451.

Levinger I, Scott D, Nicholson GC, Stuart AL, Duque G, McCorquodale T, et al. Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women. Bone. 2014;64:8-12.

Hamrick MW. A role for myokines in muscle-bone interactions. Exerc Sport Sci Rev. 2011;39(1):43.

Novotny SA, Warren GL, Hamrick MW. Aging and the muscle-bone relationship. Physiology. 2015;30(1):8-16.

Barón G. Prevalencia de osteopenia y osteoporosis en la población post-menopáusica. Rev Col Menopaus. 2002;8(1):25-32.

Schoenau E, Fricke O. Mechanical influences on bone development in children. Eur J Endocrinol. 2008;159(suppl 1):S27-31.

Gray M, Di Brezzo R, Fort IL. The effects of power and strength training on bone mineral density in premenopausal women. J Sports Med Phys Fit. 2013;53(4):428-36.

Szulc P, Blaizot S, Boutroy S, Vilayphiou N, Boonen S, Chapurlat R. Impaired bone microarchitecture at the distal radius in older men with low muscle mass and grip strength: the STRAMBO study. J Bone Miner Res. 2013;28(1):169-78.

Tachiki T, Kouda K, Dongmei N, Tamaki J, Iki M, Kitagawa J, et al. Muscle strength is associated with bone health independently of muscle mass in postmenopausal women: the Japanese population-based osteoporosis study. J Bone Miner Metab. 2017;1-7.

Pasco JA, Holloway KL, Brennan-Olsen SL, Moloney DJ, Kotowicz MA. Muscle strength and areal bone mineral density at the hip in women: a cross-sectional study. BMC Musculoskelet Disord. 2015;16(1):124.

Gomez F, Curcio CL, Henao GM. Fragilidad en ancianos colombianos. Rev Med Sanitas. 2012;15(4):8-16.

Herrero Pérez LJ. Relación entre la fuerza y la masa muscular esquelética en un grupo de ancianos institucionalizados. 2015;

Ho-Pham LT, Nguyen UD, Nguyen TV. Association between lean mass, fat mass, and bone mineral density: a meta-analysis. J Clin Endocrinol Metab. 2014;99(1):30-8.

Ma Y, Fu L, Jia L, Han P, Kang L, Yu H, et al. Muscle strength rather than muscle mass is associated with osteoporosis in older Chinese adults. J Formos Med Assoc. 2017;

Fernández C, Oliveri B, Bagur A, Glorioso DG, González D, Mastaglia S. High Prevalence of Sarcopenia in Women with Osteoporotic Fractures. J Osteopor Phys Act. 2016;4(181):2.

Hida T, Shimokata H, Sakai Y, Ito S, Matsui Y, Takemura M, et al. Sarcopenia and sarcopenic leg as potential risk factors for acute osteoporotic vertebral fracture among older women. Eur Spine J. 2016;25(11):3424-31.

Sjöblom S, Suuronen J, Rikkonen T, Honkanen R, Kröger H, Sirola J. Relationship between postmenopausal osteoporosis and the components of clinical sarcopenia. Maturitas. 2013;75(2):175-80.

Iolascon G, Giamattei MT, Moretti A, Di Pietro G, Gimigliano F, Gimigliano R. Sarcopenia in women with vertebral fragility fractures. Aging Clin Exp Res. 2013;25(1):129-31.

Trajanoska K, Schoufour JD, Darweesh SK, Medina‐Gomez C, Alfernik LJ, Lahousse L, et al. Sarcopenia and its clinical correlates in the general population: the Rotterdam Study. J Bone Miner Res. 2018;

Orsatti FL, Nahas EA, Nahas-Neto J, Orsatti CL, Marocolo M, Barbosa-Neto O, et al. Low appendicular muscle mass is correlated with femoral neck bone mineral density loss in postmenopausal women. BMC Musculoskelet Disord. 2011;12(1):225.

Huovinen V, Ivaska KK, Kiviranta R, Bucci M, Lipponen H, Sandboge S, et al. Bone mineral density is increased after a 16-week resistance training intervention in elderly women with decreased muscle strength. Eur J Endocrinol. 2016;175(6):571-82.

Refbacks

  • There are currently no refbacks.