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Published November 11, 2019
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Segmental Longitudinal Strain (SLS)
Global Longitudinal Strain (GLS)
Coronary Artery Disease (CAD)

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Radfar, M., Ashrafi, M., Sheikhvatan, M., Sadeghian, A., & Sadeghian, H. (2019). Determining the Changes in Value of Segmental Longitudinal Strain and Global Longitudinal Strain in Discriminating Left Anterior Descending Artery Involvement. Internal Medicine and Medical Investigation Journal, 4(3). https://doi.org/10.24200/imminv.v4i3.225

Determining the Changes in Value of Segmental Longitudinal Strain and Global Longitudinal Strain in Discriminating Left Anterior Descending Artery Involvement: SLS and GLS Changes in Discriminating LADA Involvement

Mehran Radfar
Department of Cardiology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
MohammadMoein Ashrafi
Young Researchers and Elites Club, Faculty of Medicine, Islamic Azad University, Yazd Branch, Yazd, Iran
Mehrdad Sheikhvatan
Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran
Afsaneh Sadeghian
Bahar Hospital, Shahrood University of Medical Science, Shahrood, Iran
Hakimeh Sadeghian
Department of Cardiology, School of Medicine, Shariati Hospital Tehran University of Medical Sciences, Tehran, Iran


Introduction: The present study was conducted to determine the predictive role of the segmental longitudinal strain in predicting left anterior descending involvement in patients with suspected coronary heart disease regarding specific cardiac segments.

Materials/Methods: This cross-sectional study was conducted on 90 consecutive patients who were candidates for coronary angiography and assessed using speckle-tracking echocardiography. All patients underwent echocardiography prior to coronary angiography and only patients with normal left ventricular ejection fraction were finally included. Besides, conventional echocardiography, all patients were subjected to speckle-tracking echocardiography determination, and the images were assessed in standard 3C, 2C, 4C views.

Results: 45 patients with left anterior descending found from the coronary angiography report and 45 patients with suspected coronary artery disease, but had normal coronary arteries. Based on the surface area under the receiver operating characteristic curve analysis, the highest diagnostic ability to distinguish between left anterior descending involvement from normal coronary state was related to the segmental longitudinal strain of the septal basal segments (AUC = 0.962), Posterior apical (AUC = 0.948), anteroseptal apical (AUC = 0.942), septal mid portion (AUC = 0.941) and inferior mid-portion (AUC = 0.911). For global longitudinal strain it was -20.45 (100% sensitivity, 95.5% specificity) regarding the global longitudinal strain diagnostic value in the prediction of left anterior descending conflict.

Conclusion: The evaluation of segmental longitudinal strain in various segments and global longitudinal strain can predict left anterior descending involvement with high sensitivity and specificity. 

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