Association between HOXB13 G84E Mutation and Risk of Prostate Cancer in Iranian patients
Objective: Prostate cancer is the second most lethal cancer in men after lung cancer in world. Genetic predisposition is fast emerging as risk factor for prostate cancer. The HOXB13 gene is a tumor suppressor gene for prostate cancer and other cancers. The present study was conducted to evaluate G84E mutation of HOXB13 in patients with prostate cancer in Kurdistan and Kermanshah provinces of Iran.
Materials and Methods: DNA was extracted from blood samples of cases of Benign Prostatic Hyperplasia (BPH) and 75 healthy control. The G84E mutation of HOXB13 was determined by direct sequencing. All statistical calculations were performed using SPSS version17.
Results: DNA sequencing results showed that the genotype of this site was GGA in all cases and controls.
Conclusion: The results of this study showed that the GOXE position of the HOXB13 gene was not associated with prostate cancer in selected patients of west Iran. This finding showed doesn’t a statistically significant difference in carrier frequency highlights the genetic predispositions to prostate cancer with respect to G84E mutation of HOXB13 gene.
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