Study of Klebsiella pneumonia Antibiotic-Resistance of K1 and K2 Serotypes in Nosocomial infections with Hospital Origin
Klebsiella Pneumonia are the most pollutants of the hospital origin. The aim of this study was to determine the antibiotic resistance pattern of Klebsiella pneumonia in two serotypes K1 and K2 from samples Collected with urinary tract infections and burn injuries in Kermanshah of Iran. This study was performed on 140 samples collected from hospitals in Kermanshah for a period of 6 months. After confirmation of bacteria by phenotypic method, genotyping was done by PCR of rmpA2 and magA1 genes. Subsequently, Antibiotic Resistance Pattern was evaluated according to the CLSI 2017 regimen using 6 types of antibiotic disks. The results of genotype determination showed that 76% of the samples were related to K1 serotype and 24% of the samples were related to K2 serotype. Also, among the samples taken from the 35 urine, K1 showed an 80% prevalence (28 samples) and 20% were related to k2. Of the 35 samples examined from burn injuries, 71% of the samples were related to K1 and 29% related to K2. The antibiogram results showed that the samples of K1 positive were resistant to Onloxacin and Nitrofurantoin antibiotics and sensitive to Ceftoxime and limit to Ceftriaxone antibiotics. The interface has the Trimethoprim and Cefazolin antibiotics. Also, K2 serotype is susceptible to Ceftoxime and resistant to Nitrofurantoin and intermediate mode for Cefazolin, Forloxacin and Trimethoprim antibiotics. Additionally, the resistance k1 serotype is higher than k2. In both samples of urine and burn in the studied population, the prevalence of serotype k1 was higher and in both groups, the most resistant to antibiotics were Nitrofurantoin and onloxacin. Also, the most commonly used antibiotics that are recommended are Cefotaxime and Ceftriaxone, and resistant antibiotics that should be used less than Nitrofurantoin and Onloxacin.
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