Effect of Sumac (Rhus coriaria) Extract on Blood Lipid Profile in White Wistar Rat

HamidReza Soltani, Alireza Vahidi, Mohammad Dehghan Tezerjani, Mohammad Javaherchian, SeyedAli Shiryazdi

Abstract

Backgrounf: Hyperlipidemia is one of the chronic diseases whose current solutions are the proper diet and chemical drugs. Evaluation of accessible medicinal plant recourses has an important role to prevent and treat the hyperlipidemia. The present study aimed to investigate the effect of sumac (Rhus coriaria) extract on blood lipid profile in white Wistar rat.

Methods: This laboratory animal experiment was conducted on 21 white Wistar rats during four weeks. The research units divided into three groups separately were fed by normal diet, fatty diet without sumac extract and fatty diet with sumac extract. The samples were excluded after appearing sick-like behaviors. Finally, data were analyzed in SPSS ver. 16 software using ANOVA and LSD tests.

Results: The mean weight of rats was 310±26 gram. The mean blood cholesterol had significant difference in fatty diet with sumac group in compared with control group from the second week to the end of study (P<0.001), also the mean triglyceride was increased significantly during the study in fatty diet with sumac extract group (P=0.47). The mean HDL and LDL had no significant change during the study (P>0.05).

Conclusion: According to the findings of this study, the use of sumac with fatty diet can be effective to reduce blood cholesterol in prevention and treatment of hyperlipidemia.

Keywords

Rhus coriaria, Hyperlipidemia, HDL, LDL, VLDL

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References

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